PhD researcher Pharmaceutical development

The predictive value of animal models in the development of pharmaceuticals. The scientific basis of the current paradigm on the predictability of animal studies for the effects of drugs in man is under discussion. There are no recent studies on their predictive value. In this ambitious project, Utrecht University will cooperate with the Medicines Evaluation Board, Nefarma, Life Sciences and Health and TI Pharma. The research team will make a complete inventory of available data concerning the capacity of research in test animals, and assess the scientific basis of the current practices and guidelines for the use of animal studies in pharmaceutical discovery and development. In addition, an assessment of alternative technologies will be performed. This study aims to supply interesting and important suggestions and implications for the regulatory guidelines in the development of new medicines.

Your tasks:

• Analysis of the predictive value of animal testing for efficacy and safety of animals in the files for approval of new drugs.
• Analysis of the use of animal tests in the release of pharmaceuticals to the market.
• Analysis of the use of animal tests in lead selection by pharmaceutical industries.
• Review literature concerning the predictive value of animal studies in pharmaceutical research.
• Assess the scientific basis of regulations regarding animal models in pharmaceutical research.
• Technology assessment of new in silico and in vitro methods to define activity and toxicity of drugs.
• Analysis of the translational problems in the process of setting up of possible alternatives to animal models.
• Survey of all legislation and regulations concerning animal studies in pharmaceutical discovery and development.
• Organization of expert groups for data evaluation.

QUALIFICATIONS

• You have experience in a relevant field, preferably with a biomedical or pharmaceutical background.
• Having experience in statistical and analytical data analysis and assessments are a plus.
• You have excellent communication skills.

TERMS OF EMPLOYMENT

The candidate is offered a full-time position for 4 years and should lead to a dissertation and PhD degree.

Gross salary starts with € 2,042.- per month in the first year and increases to € 2,612.- in the fourth year of employment.

The salary is supplemented with a holiday bonus of 8% and an end-of-year bonus of 8,3% per year. In addition we offer: a pension scheme, a partially paid parental leave, flexible employment conditions in which you may trade salary for vacation days or vice versa. Conditions are based on the Collective Employment Agreement of the Dutch Universities. The research group will provide the candidate with necessary support on all aspects of the project.

DEADLINE

31-12-2009

FURTHER INFORMATION

http://applicaties.csc.uu.nl/uuvacature/mainframe.cfm?vacatures=all&taal=Engels